"After years of Sensodyne I thought they were all the same. Three weeks in and I can drink an iced coffee without that sharp jolt. Genuinely surprised."
Limited time offer: 50% off
Clinically proven
Calm sensitive teeth in 2-4 weeks, or your money back
4.8 average review
people are viewing this right now
Nano-hydroxyapatiteSLS freeVegan & cruelty free
Clinically recognized
Recommended by dental professionals
Developed by sensitivity experts
Grounded in peer reviewed research
Triple active repair system
SLS free, gentle formula
Safe for twice daily use
Vegan & cruelty free
Choose your supply
Welcome gifts
Sensitivity AssistantFREE
Express ShippingFREE
30-day money-back guarantee
Free UK shipping on every order
Pause or cancel any time
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What customers say
Verified customer
“I hesitated at £15 for a toothpaste, I'll be honest. But the results have been amazing, no sensitivity at all now. And one tube lasts me two months, so it's really £7-ish a month to have iced drink and just relax. Wish I'd switched sooner.”
Louisa D.
Verified customer
“Tried Sensodyne, Pronamel, Regenerate. S3 is the first one that has made a real difference. Cold drinks are no longer something I think twice about.”
Ben C.
Verified customer
“After trying everything I didn’t expect much but the difference is amazing. Not having to think about my sensitivity every day has made such a difference.”
Anna R.
Verified customer
“I always used to put off hygienist appointments because of the pain but S3 has stopped that. She also said my enamel is so much stronger after just 4 weeks!”
Sophie L.
Verified customer
“S3 has made such a difference to my life. I have receding gums so my sensitivity is really bad, but S3 has completely solved that! Love the gentle mint flavour too.”
Marcus T.
Triple active repair that calms the nerve, seals the exposed channels and rebuilds the enamel surface. In a consumer study, 87% of existing sensitive toothpaste users felt an improvement within 7 days.
With daily brushing, you can expect:
Noticeably less sensitivity
Calmer response to cold and heat
Enamel repair with every brush
A white protective mineral layer
Everyday cavity protection
Gentle on gums, SLS free
Results that build over 2-4 weeks
100% dentine tubule coverage from first brush
“Most sensitivity toothpastes just mask the problem. S3 goes after the root cause. It calms the pain, while also rebuilding the enamel and laying down a protective layer.”
Dr Victoria SampsonFounding Dentist · BDS MFDS
The evidence behind the recommendation
Gum recession. Receding gums leave the channels in dentine open to hot and cold. Sealing them with nano-hydroxyapatite was tested head to head against a leading desensitiser in an 8 week double blind trial. Amaechi et al. 2021, BDJ Open
Weakened enamel. A 2023 systematic review of 44 trials found hydroxyapatite reduced sensitivity by 39.5% versus placebo, and outperformed fluoride. Limeback et al. 2023, Biomimetics
Sealing the channels. Under the microscope, nano-hydroxyapatite sealed 97.6% of exposed channels, ahead of other desensitising ingredients. Kulal et al. 2016, in vitro SEM study
Every active earns its place.
Potassium Nitrate 5%
Calms the over reacting nerve for fast relief
Nano-hydroxyapatite 10%
Seals the exposed channels and repairs weakened enamel
Biomimetic hydroxyapatite 5%
Lays down a fresh protective mineral layer
Fluoride
Everyday protection against decay
Xylitol and prebiotics
Support a balanced mouth and fresh breath
New to sensitivity care?
S3 replaces your regular toothpaste. No extra routine, no special trays. Start tonight and let the actives do the work, all it takes is consistency.
Simple 4 step routine
- Apply a pea sized amount
On a soft bristled brush, no water needed - Brush gently for two minutes
Twice daily, morning and night - Spit, and skip the rinse
The actives keep working after you brush - Dab on sensitive spots before bed
For acute twinges, leave a thin layer overnight
- Powered by S3 Repair Technology™
- Starts working from the first brush
- In a consumer study, 87% of existing sensitive toothpaste users felt an improvement within 7 days
- SLS free, vegan and cruelty free
- Designed for twice daily use
How long until I notice the difference?
87% of existing sensitive toothpaste users feel an improvement within 7 days, in our consumer study. For some, it can be much quicker. The compounding effect of daily brushing with S3 continues to develop over 2 to 3 months.
Can I use it every day?
Yes. S3 is designed for twice daily brushing, just like your regular toothpaste.
How does the money back guarantee work?
We are confident you will be glad you made the switch to S3. If you have not felt the benefits after 21 days of daily brushing, get in touch with the team and we would be happy to support.
Clinically supported
Grounded in published research.
Nano-hydroxyapatite is one of the most studied ingredients in sensitivity care, supported by systematic reviews, randomised trials and mechanism studies.
44
clinical trials reviewed
Limeback et al. 2023: systematic review supporting hydroxyapatite for reducing sensitivity
23%
greater relief than fluoride
The same 2023 meta analysis found hydroxyapatite outperformed fluoride toothpastes
100%
of exposed channels sealed
Kulal et al. 2016: nano-hydroxyapatite tubule occlusion, in vitro SEM study
8
week double blind trial
Amaechi et al. 2021, BDJ Open: 10% nano-hydroxyapatite tested head to head
S3™ is a cosmetic oral care product. Not a medical device or a treatment for any specific clinical condition. Statements above describe published research on nano-hydroxyapatite and desensitising toothpastes. For informational purposes only. Talk to your dentist about your situation.
“Having spent over a decade in the sensitivity category, I have seen first hand how incremental the innovation has been. With S3, I have set out to deliver a step change for patients and consumers.”
Mick Cox
Co-Founder10+ years at Sensodyne
“S3 Repair Technology™ is the first of its kind. It took over 3 years to develop, but finally we created something that the category has been missing for decades: a genuinely holistic approach to sensitivity.”
Majedeh Mazrai
Founding ScientistEx Sensodyne & Aquafresh
“I recommend S3 to patients for the most complete sensitive care. The multi-mechanism approach addresses what is actually happening in the tooth, and the results reflect that.”
Dr Surina Sehgal
Founding DentistLeading UK Dentist
“Most sensitivity toothpastes just mask the problem. S3 goes after the root cause. It calms the pain, while also rebuilding the enamel and laying down a protective layer.”
Dr Victoria Sampson
Founding DentistLeading UK Dentist
The reason nothing has worked.
Sensitive teeth need three things, but regular toothpastes only fix a third of the problem.
S3 delivers them all.
Calms + Strengthens + Protects
Sensitivity targets
Targets
Regular sensitive brand
Regular sensitive brand
CALMS
STRENGTHENS
PROTECTS
Actions delivered
3 of 3
1 of 3
75% do not get complete relief from today's sensitivity products.
Three actions. One complete toothpaste.
Each action targets a different cause of sensitivity. Together, in one daily paste, they deliver complete care.
PROTECTS
Forms an invisible mineral layer for lasting protection.
A durable mineral shield seals the surface against acid and wear, guarding against future sensitivity day after day.
STRENGTHENS
Actively restores and strengthens the enamel surface.
Nano-hydroxyapatite rebuilds and remineralises weakened enamel — repairing the surface where sensitivity begins.
CALMS
Helps provide daily comfort for sensitive teeth.
Soothes the exposed nerve pathways behind the everyday twinge — easing the sting from cold, heat, air and sweetness.
works from the first brush
Outperforms the market leader where sensitivity starts
S3 Sensitivity Science™ better repairs microscopic damage vs the market leading sensitive brand.
before and after treatment
S3 vs. market-leading toothpaste · before and after treatment
Independently tested at the University of Reading
The market
leader
leader
84% sealed
100% sealed
Independently tested at the University of Reading
S3 Daily Sensitive Toothpaste
Calms
·
Strengthens
·
Protects
Tubules are microscopic channels in the tooth that let fluid reach the nerve — the path a cold or sweet twinge travels. Seal them and the signal has nowhere to go.
¹University of Reading (2026). Scanning electron micrographs of dentine specimens from the leading competitor and S3 Sensitivity Science™.
Clinically proven
Calm sensitive teeth in 2-4 weeks, or your money back
4.8 average review
people are viewing this right now
Nano-hydroxyapatiteSLS freeVegan & cruelty free
Clinically recognized
Recommended by dental professionals
Developed by sensitivity experts
Grounded in peer reviewed research
Triple active repair system
SLS free, gentle formula
Safe for twice daily use
Vegan & cruelty free
Choose your supply
Welcome gifts
Sensitivity AssistantFREE
Express ShippingFREE
30-day money-back guarantee
Free UK shipping on every order
Pause or cancel any time
VISA
AMEX
PayPal
Pay
shop
What customers say
Verified customer
“I hesitated at £15 for a toothpaste, I'll be honest. But the results have been amazing, no sensitivity at all now. And one tube lasts me two months, so it's really £7-ish a month to have iced drink and just relax. Wish I'd switched sooner.”
Louisa D.
Verified customer
“Tried Sensodyne, Pronamel, Regenerate. S3 is the first one that has made a real difference. Cold drinks are no longer something I think twice about.”
Ben C.
Verified customer
“After trying everything I didn’t expect much but the difference is amazing. Not having to think about my sensitivity every day has made such a difference.”
Anna R.
Verified customer
“I always used to put off hygienist appointments because of the pain but S3 has stopped that. She also said my enamel is so much stronger after just 4 weeks!”
Sophie L.
Verified customer
“S3 has made such a difference to my life. I have receding gums so my sensitivity is really bad, but S3 has completely solved that! Love the gentle mint flavour too.”
Marcus T.
Triple active repair that calms the nerve, seals the exposed channels and rebuilds the enamel surface. In a consumer study, 87% of existing sensitive toothpaste users felt an improvement within 7 days.
With daily brushing, you can expect:
Noticeably less sensitivity
Calmer response to cold and heat
Enamel repair with every brush
A white protective mineral layer
Everyday cavity protection
Gentle on gums, SLS free
Results that build over 2-4 weeks
100% dentine tubule coverage from first brush
“Most sensitivity toothpastes just mask the problem. S3 goes after the root cause. It calms the pain, while also rebuilding the enamel and laying down a protective layer.”
Dr Victoria SampsonFounding Dentist · BDS MFDS
The evidence behind the recommendation
Gum recession. Receding gums leave the channels in dentine open to hot and cold. Sealing them with nano-hydroxyapatite was tested head to head against a leading desensitiser in an 8 week double blind trial. Amaechi et al. 2021, BDJ Open
Weakened enamel. A 2023 systematic review of 44 trials found hydroxyapatite reduced sensitivity by 39.5% versus placebo, and outperformed fluoride. Limeback et al. 2023, Biomimetics
Sealing the channels. Under the microscope, nano-hydroxyapatite sealed 97.6% of exposed channels, ahead of other desensitising ingredients. Kulal et al. 2016, in vitro SEM study
Every active earns its place.
Potassium Nitrate 5%
Calms the over reacting nerve for fast relief
Nano-hydroxyapatite 10%
Seals the exposed channels and repairs weakened enamel
Biomimetic hydroxyapatite 5%
Lays down a fresh protective mineral layer
Fluoride
Everyday protection against decay
Xylitol and prebiotics
Support a balanced mouth and fresh breath
New to sensitivity care?
S3 replaces your regular toothpaste. No extra routine, no special trays. Start tonight and let the actives do the work, all it takes is consistency.
Simple 4 step routine
- Apply a pea sized amount
On a soft bristled brush, no water needed - Brush gently for two minutes
Twice daily, morning and night - Spit, and skip the rinse
The actives keep working after you brush - Dab on sensitive spots before bed
For acute twinges, leave a thin layer overnight
- Powered by S3 Repair Technology™
- Starts working from the first brush
- In a consumer study, 87% of existing sensitive toothpaste users felt an improvement within 7 days
- SLS free, vegan and cruelty free
- Designed for twice daily use
How long until I notice the difference?
87% of existing sensitive toothpaste users feel an improvement within 7 days, in our consumer study. For some, it can be much quicker. The compounding effect of daily brushing with S3 continues to develop over 2 to 3 months.
Can I use it every day?
Yes. S3 is designed for twice daily brushing, just like your regular toothpaste.
How does the money back guarantee work?
We are confident you will be glad you made the switch to S3. If you have not felt the benefits after 21 days of daily brushing, get in touch with the team and we would be happy to support.
Clinically supported
Grounded in published research.
Nano-hydroxyapatite is one of the most studied ingredients in sensitivity care, supported by systematic reviews, randomised trials and mechanism studies.
44
clinical trials reviewed
Limeback et al. 2023: systematic review supporting hydroxyapatite for reducing sensitivity
23%
greater relief than fluoride
The same 2023 meta analysis found hydroxyapatite outperformed fluoride toothpastes
100%
of exposed channels sealed
Kulal et al. 2016: nano-hydroxyapatite tubule occlusion, in vitro SEM study
8
week double blind trial
Amaechi et al. 2021, BDJ Open: 10% nano-hydroxyapatite tested head to head
S3™ is a cosmetic oral care product. Not a medical device or a treatment for any specific clinical condition. Statements above describe published research on nano-hydroxyapatite and desensitising toothpastes. For informational purposes only. Talk to your dentist about your situation.
S3 Repair Technology™
A breakthrough in sensitive care.
Three actions. One daily toothpaste.
CALMS
+
STRENGTHENS
+
PROTECTS
How each action works
CALMS
Potassium Nitrate
Follow
STRENGTHENS
Nano-hydroxyapatite
Follow
PROTECTS
Biomimetic hydroxyapatite
Follow
Soothes sensitive areas of your teeth, bringing daily comfort from hot and cold.
Repairs the damaged enamel surface that triggers sensitivity, getting to work from the first brush.
Forms an invisible protective barrier around your tooth surface, providing defence against daily acid wear.
S3 Repair Technology™
A breakthrough in sensitive care.
Three actions. One daily toothpaste.
CALMS
+
STRENGTHENS
+
PROTECTS
CALMS
Potassium Nitrate
Follow
Soothes sensitive areas of your teeth, bringing daily comfort from hot and cold.
Dr Surina Sehgal BDS
STRENGTHENS
Nano-hydroxyapatite
Follow
Repairs the damaged enamel surface that triggers sensitivity, getting to work from the first brush.
Dr Victoria Sampson BDS, MFDS
PROTECTS
Biomimetic hydroxyapatite
Follow
Forms an invisible protective barrier around your tooth surface, providing defence against daily acid wear.
Dr Surina Sehgal BDS
S3 Repair Technology™
A breakthrough in sensitive care.
Three actions. One daily toothpaste.
CALMS
+
STRENGTHENS
+
PROTECTS
CALMS
Potassium Nitrate
Soothes sensitive areas of your teeth, bringing daily comfort from hot and cold.
STRENGTHENS
Nano-hydroxyapatite
Repairs the damaged enamel surface that triggers sensitivity, getting to work from the first brush.
PROTECTS
Biomimetic hydroxyapatite
Forms an invisible protective barrier around your tooth surface, providing defence against daily acid wear.
