“Having spent over a decade in the sensitivity category, I have seen first hand how incremental the innovation has been. With S3, I have set out to deliver a step change for patients and consumers.”
Mick Cox
Co-Founder10+ years at Sensodyne
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What customers say
Verified customer
“I hesitated at £15 for a toothpaste, I'll be honest. But the results have been amazing, no sensitivity at all now. And one tube lasts me two months, so it's really £7-ish a month to have iced drink and just relax. Wish I'd switched sooner.”
Louisa D.
Verified customer
“Tried Sensodyne, Pronamel, Regenerate. S3 is the first one that has made a real difference. Cold drinks are no longer something I think twice about.”
Ben C.
Verified customer
“I've noticed my teeth are much brighter and healthier switching to S3. The enamel is stronger and surface cracks are now smooth and repaired!”
Anna R.
Verified customer
“I always used to put off hygienist appointments because of the pain but S3 has stopped that. She also said my enamel is so much stronger after just 4 weeks!”
Sophie L.
Verified customer
“S3 has made such a difference to my life. I have receding gums so my sensitivity is really bad, but S3 has completely solved that! Love the gentle mint flavour too.”
Marcus T.
S3 Daily Care Toothpaste works to restore, strengthen and whiten teeth through its unique triple-active technology.
With daily brushing, you can expect:
Noticeably less sensitivity
Calmer response to cold and heat
Enamel repair with every brush
A white protective mineral layer
Everyday cavity protection
Gentle on gums, SLS free
Results that build over 2-4 weeks
100% dentine tubule coverage from first brush
“Most sensitivity toothpastes just mask the problem. S3 goes after the root cause. It calms the pain, while also rebuilding the enamel and laying down a protective layer.”
Dr Victoria SampsonFounding Dentist · BDS MFDS
The evidence behind the recommendation
Gum recession. Receding gums leave the channels in dentine open to hot and cold. Sealing them with nano-hydroxyapatite was tested head to head against a leading desensitiser in an 8 week double blind trial. Amaechi et al. 2021, BDJ Open
Weakened enamel. A 2023 systematic review of 44 trials found hydroxyapatite reduced sensitivity by 39.5% versus placebo, and outperformed fluoride. Limeback et al. 2023, Biomimetics
Sealing the channels. Under the microscope, nano-hydroxyapatite sealed 97.6% of exposed channels, ahead of other desensitising ingredients. Kulal et al. 2016, in vitro SEM study
Typical toothpastes are 0-5% active. S3's unique formula contains 27% of active ingredients to provide superior protection and care.
Potassium Nitrate 5%
Calms the over reacting nerve for fast relief
Nano-hydroxyapatite 10%
Seals the exposed channels and repairs weakened enamel
Biomimetic hydroxyapatite 5%
Lays down a fresh protective mineral layer
Fluoride (1450 ppm)
Everyday protection against decay
Xylitol and prebiotics (7%)
Support a balanced mouth and fresh breath
Full ingredients:
Glycerin, Sorbitol, Hydrated Silica, Aqua, Hydroxyapatite, Potassium Nitrate, Xylitol, Hydroxyapatite (nano), Sodium Monofluorophosphate, Poloxamer 407, Sodium Lauroyl Sarcosinate , Aroma, Xanthan Gum, Potassium Chloride, Cocamidopropyl Betaine, Carageenan, Phenylpropanol, o-Cymen-5-ol, Decylene Glycol, Sodium Saccharin, Titanium Dioxide, Potassium Hydroxide, Menthol, Anethole, Mentha Piperita Oil, Limonene, Citrus Limon Peel Oil.
New to sensitivity care?
S3 replaces your regular toothpaste. No extra routine, no special trays. Start tonight and let the actives do the work, all it takes is consistency.
Simple 4 step routine
- Apply a pea sized amount
On a soft bristled brush, no water needed - Brush gently for two minutes
Twice daily, morning and night - Spit, and skip the rinse
The actives keep working after you brush - Dab on sensitive spots before bed
For acute twinges, leave a thin layer overnight
- Powered by S3 Repair Technology™
- Starts working from the first brush
- In a consumer study, 87% of existing sensitive toothpaste users felt an improvement within 7 days
- SLS free, vegan and cruelty free
- Designed for twice daily use
How long until I notice the difference?
87% of existing sensitive toothpaste users feel an improvement within 7 days, in our consumer study. For some, it can be much quicker. The compounding effect of daily brushing with S3 continues to develop over 2 to 3 months.
Can I use it every day?
Yes. S3 is designed for twice daily brushing, just like your regular toothpaste.
How does the money back guarantee work?
We are confident you will be glad you made the switch to S3. If you have not felt the benefits after 21 days of daily brushing, get in touch with the team and we would be happy to support.
calms - strengthens - protects
A breakthrough triple-active daily toothpaste
Healthy teeth need three things. S3 is the only toothpaste that brings them together into one daily formula.
“S3 Repair Technology™ is the first of its kind. It took over 3 years to develop, but finally we created something that the category has been missing for decades: a genuinely holistic approach to sensitivity.”
Majedeh Mazrai
Founding ScientistEx Sensodyne & Aquafresh
“I recommend S3 to patients for the most complete sensitive care. The multi-mechanism approach addresses what is actually happening in the tooth, and the results reflect that.”
Dr Surina Sehgal
Founding DentistLeading UK Dentist
“Most sensitivity toothpastes just mask the problem. S3 goes after the root cause. It calms the pain, while also rebuilding the enamel and laying down a protective layer.”
Dr Victoria Sampson
Founding DentistLeading UK Dentist
