“S3 is the first one that has made a real difference. Cold drinks are no longer something I think twice about.”

— Ben C., Cambridge
  • Cavity protection
  • Advanced sensitive care
  • Provides daily freshness
  • Supports gum health
  • Oral-microbiome balancing
  • No SLS or artificial preservatives
  • Potassium Nitrate 5% — calms the nerve directly. Sensitivity relief from the first brush.
  • Nano-Hydroxyapatite 10% — physically seals exposed dentine. Up to 98% tubule occlusion after seven days.
  • Biomimetic Hydroxyapatite 5% — forms a protective mineral layer with every brush. Keeps rebuilding throughout the day.
  • Sodium Fluoride 1450ppm — dentist-recommended cavity protection. Works in synergy with the hydroxyapatite system.
  • Prebiotics — reduces bad bacteria and supports a balanced oral microbiome.

Most sensitive toothpastes address sensitivity one way. S3 uses a breakthrough triple active technology to address it three ways simultaneously: calming the nerve, sealing the exposed channels that cause pain, and rebuilding the enamel surface. The result is more complete relief, for more people, including those who have not found adequate relief elsewhere.

The right toothpaste can change your life.

  • Feel the difference

    87% notice improvement within 7 days.

  • Clinically proven

    Most advanced sensitivity toothpaste.

  • Trust your teeth

    Every brush strengthens your enamel.

  • Designed for you

    Tested on people with sensitivity.

Recommended by leading UK dentists.

Dr Victoria Sampson

“Most sensitivity toothpastes just mask the problem. S3 goes after the root cause. It calms the pain, while also rebuilding the enamel and laying down a protective layer.”

Dr Victoria Sampson

BDS MFDS

Dr Surina Seghal

“I recommend S3 to patients for the most complete sensitive care. The multi-mechanism approach addresses what is actually happening in the tooth, and the results reflect that.”

Dr Surina Seghal

BDS

Dr Joe Bloggs

“Everyone thinks sensitive teeth is just something you live with. It's not. You've just been using toothpastes that only solve a third of the problem. S3 tackles all the root causes.”

Dr Joe Bloggs

BDS MFDS

How S3 is different.

Most toothpastes try to address sensitivity by using one single active ingredient, often only masking the pain.

S3 takes a holistic approach to sensitive care. Our breakthrough S3 Repair Technology™ targets sensitivity in three ways in one single daily formula.

  • Calms

    Helps provide daily comfort for sensitive teeth.

  • Strengthens

    Actively restores and strengthens enamel surface.

  • Protects

    Forms an invisible mineral layer for lasting protection.

Calms

Directly calms the nerve and provides daily comfort for sensitive teeth.

Ingredient

POTASSIUM NITRATE 5%

KNO₃+

Potassium nitrate works by penetrating the tooth and calming the nerve directly, rather than simply blocking sensation at the surface. Used consistently in a daily toothpaste, it offers patients real, ongoing relief rather than a short-term fix.

Dr Surina Seghal, BDS Dr Surina Seghal, BDS

Strengthens

Actively restores and strengthens the enamel surface, repairing damage 2× more effectively than the market leader.

Ingredient

NANO-HYDROXYAPATITE 10%

n-HAP

Nano-hydroxyapatite at 10% doesn't just protect enamel, it restores it at a structural level, with clinical evidence showing twice the repair efficacy of leading alternatives.

Dr Victoria Sampson, BDS MFDS Dr Victoria Sampson, BDS MFDS

Protects

Forms an invisible mineral layer around the tooth that activates when your enamel needs it most.

Ingredient

Biomimetic Hydroxyapatite 5%

Ca₁₀(PO₄)₆(OH)₂

Biomimetic hydroxyapatite is especially compelling because it behaves like the mineral your teeth are naturally made from. It forms a protective layer over enamel that helps shield vulnerable areas from acid attack and everyday wear, giving teeth an added level of defence exactly when they need it most.

Dr Victoria Sampson, BDS MFDS Dr Victoria Sampson, BDS MFDS

Calms

Directly calms the nerve and provides daily comfort for sensitive teeth.

Ingredient

POTASSIUM NITRATE 5%

KNO₃+

Potassium nitrate works by penetrating the tooth and calming the nerve directly, rather than simply blocking sensation at the surface. Used consistently in a daily toothpaste, it offers patients real, ongoing relief rather than a short-term fix.

Dr Surina Seghal, BDS Dr Surina Seghal, BDS

Strengthens

Actively restores and strengthens the enamel surface, repairing damage 2× more effectively than the market leader.

Ingredient

NANO-HYDROXYAPATITE 10%

n-HAP

Nano-hydroxyapatite at 10% doesn't just protect enamel, it restores it at a structural level, with clinical evidence showing twice the repair efficacy of leading alternatives.

Dr Victoria Sampson, BDS MFDS Dr Victoria Sampson, BDS MFDS

Protects

Forms an invisible mineral layer around the tooth that activates when your enamel needs it most.

Ingredient

Biomimetic Hydroxyapatite 5%

Ca₁₀(PO₄)₆(OH)₂

Biomimetic hydroxyapatite is especially compelling because it behaves like the mineral your teeth are naturally made from. It forms a protective layer over enamel that helps shield vulnerable areas from acid attack and everyday wear, giving teeth an added level of defence exactly when they need it most.

Dr Victoria Sampson, BDS MFDS Dr Victoria Sampson, BDS MFDS

See the difference under the microscope.

In an independent study by the University of Reading, S3 provided greater coverage of the exposed tooth surface than the leading sensitive toothpaste.¹

What are dentine tubules?

Dentinal tubules are microscopic channels that run from the tooth surface to the nerve. When they are exposed, external stimuli travel through them and trigger sensitivity. S3 provides near-complete mineral coverage. The route to the nerve is sealed.

¹University of Reading (2026) Scanning electron micrographs of dentine specimens from the leading competitor and S3 groups after polishing, citric acid etching, saline and treatment application, and washing.

Benefits that build over time.

Designed for daily use, S3 works progressively — building stronger protection with every brush.

  1. 1 Day Active protection
    • Biomimetic hydroxyapatite begins forming a mineral layer on enamel.
    • Teeth feel smoother after the very first use
    • Active protection from the first brush
  2. 2 Days Quick comfort
    • 87% report meaningful sensitivity improvement.
    • Triple active system seals, calms and protects
    • Noticeable relief within the first week
  3. 14–28 Days Deep protection
    • Nano-hydroxyapatite seals exposed dentinal tubules.
    • Cold, heat and pressure triggers reduce
    • Sensitivity continues to decrease with use
  4. 28–90 Days Lasting strength
    • Builds real structural enamel strength.
    • Enamel remineralised with consistent use
    • Sensitivity managed at source, not masked

How S3 compares.

 
Others
No. of sensitivity causes covered
3
1
Tubule occlusion
Up to 98% after 7 days
Partial
Enamel repair
Dual hydroxyapatite + Fluoride
Fluoride only
Active concentrations
Clinically validated levels
Not disclosed
SLS-free
Yes
Not often
Fluoride
1450ppm
1450ppm
Independently validated
Yes (University of Reading)
Yes

Sensitivity stories

From people who have tried everything else.

“Tried Sensodyne, Pronamel, Regenerate. S3 is the first one that has made a real difference. Cold drinks are no longer something I think twice about.”
“After trying everything I didn’t expect much but the difference is amazing. Not having to think about my sensitivity every day has made such a difference.”
“I always used to put off hygienist appointments because of the pain but S3 has stopped that. She also said my enamel is so much stronger after just 4 weeks!”
“S3 has made such a difference to my life. I have receding gums so my sensitivity is really bad, but S3 has completely solved that! Love the gentle mint flavour too.”

Common questions.

Most people notice a reduction in sensitivity within the first three days. 87% of users in our study reported meaningful improvement within seven days. For some, particularly those with more severe or long-standing sensitivity, the full benefit builds over four to six weeks as the hydroxyapatite system progressively strengthens the enamel surface.

Sensodyne primarily works through a single mechanism, either potassium nitrate or strontium acetate depending on the variant. S3 addresses sensitivity three ways simultaneously: nerve desensitisation, dentinal tubule occlusion, and enamel remineralisation. The combination delivers faster initial relief and longer-term structural improvement that single-mechanism products cannot match.

Yes. S3 is designed as a daily toothpaste, used morning and evening in place of your regular toothpaste. All active ingredients are at clinically validated concentrations. The formula is SLS-free and microbiome-friendly, making it suitable for long-term daily use.

Yes. S3 contains 1450ppm sodium fluoride, the standard concentration for adult cavity prevention. There is a common misconception that hydroxyapatite and fluoride compete. They do not. They work in complementary ways, and S3 is formulated to optimise both.

S3 is formulated for adults. For children under 12, we recommend consulting your dentist before use. The fluoride concentration is at the adult-standard level, which may not be appropriate for younger children.

S3 is designed for anyone who experiences sensitivity to hot, cold, sweet, or acidic food and drink, and particularly for people who have not found adequate relief from existing sensitive toothpastes. Suitable for daily use as a complete toothpaste, not just a sensitivity treatment. Contains fluoride at 1450ppm. Safe for adults and children over 12. If you are pregnant, breastfeeding, or have an existing dental condition, we recommend checking with your dentist first.

S3 was formulated to solve sensitivity, but the ingredients that make it work also make it one of the most complete daily toothpastes available. Nano-hydroxyapatite actively repairs and remineralises enamel. Biomimetic hydroxyapatite strengthens the tooth surface with every brush. Prebiotics support a balanced oral microbiome. Fluoride at 1450ppm protects against cavities. If you care about your oral health and want a toothpaste that does more than clean your teeth, S3 is a meaningful upgrade.

We offer a 30-day money back guarantee on all orders. If you do not notice a difference within 30 days, contact us and we will refund your order in full. No complicated returns process.


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